SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents. / Scherag, André; Kleber, Michaela; Boes, Tanja; Kolbe, Andreea-Liliana; Ruth, Anne; Grallert, Harald; Illig, Thomas; Heid, Iris M; Toschke, André M; Grau, Katrine; Sørensen, Thorkild I A; Hebebrand, Johannes; Hinney, Anke; Reinehr, Thomas; NUGENOB Consortium.

In: Obesity, Vol. 20, No. 2, 2012, p. 466-70.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Scherag, A, Kleber, M, Boes, T, Kolbe, A-L, Ruth, A, Grallert, H, Illig, T, Heid, IM, Toschke, AM, Grau, K, Sørensen, TIA, Hebebrand, J, Hinney, A, Reinehr, T & NUGENOB Consortium 2012, 'SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents', Obesity, vol. 20, no. 2, pp. 466-70. https://doi.org/10.1038/oby.2011.339

APA

Scherag, A., Kleber, M., Boes, T., Kolbe, A-L., Ruth, A., Grallert, H., Illig, T., Heid, I. M., Toschke, A. M., Grau, K., Sørensen, T. I. A., Hebebrand, J., Hinney, A., Reinehr, T., & NUGENOB Consortium (2012). SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents. Obesity, 20(2), 466-70. https://doi.org/10.1038/oby.2011.339

Vancouver

Scherag A, Kleber M, Boes T, Kolbe A-L, Ruth A, Grallert H et al. SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents. Obesity. 2012;20(2):466-70. https://doi.org/10.1038/oby.2011.339

Author

Scherag, André ; Kleber, Michaela ; Boes, Tanja ; Kolbe, Andreea-Liliana ; Ruth, Anne ; Grallert, Harald ; Illig, Thomas ; Heid, Iris M ; Toschke, André M ; Grau, Katrine ; Sørensen, Thorkild I A ; Hebebrand, Johannes ; Hinney, Anke ; Reinehr, Thomas ; NUGENOB Consortium. / SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents. In: Obesity. 2012 ; Vol. 20, No. 2. pp. 466-70.

Bibtex

@article{fd56c40fd88e46f6b4cc27781cafe289,
title = "SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents",
abstract = "Genome-wide association analyses (GWAS) contributed to the detection of a number of single-nucleotide polymorphisms (SNPs) associated with obesity. However, little is known about the impact of the obesity-risk alleles on weight loss-related phenotypes after lifestyle interventions. A recent meta-analysis of GWAS reported five genomic loci near or in the genes FTO, MC4R, TMEM18, SDCCAG8, TNKS/MSRA that were associated with obesity in children and adolescents. Here, we analyzed the effect of the 10 SNPs representative of the five loci on measures of weight loss and cardiometabolic risk after a 1-year lifestyle intervention in 401 children and adolescents (mean age 10.74 years; 55.4% female; mean BMI 27.42 kg/m(2), mean BMI-standard deviation score (SDS) 2.37). For confirmation of one locus genotyping of three intronic SNPs in SDCCAG8 was performed in 626 obese adults who completed the 10-week hypoenergetic diet program. Intronic variants of SDCCAG8, which are associated with early onset obesity, are associated with reduced weight loss after a 1-year lifestyle intervention in overweight children and adolescents even after adjusting for age, sex, baseline measurement, or multiple testing (all P <10(-6)). However, our results could not be confirmed in 626 obese adults undertaking a hypoenergetic diet intervention.",
author = "Andr{\'e} Scherag and Michaela Kleber and Tanja Boes and Andreea-Liliana Kolbe and Anne Ruth and Harald Grallert and Thomas Illig and Heid, {Iris M} and Toschke, {Andr{\'e} M} and Katrine Grau and S{\o}rensen, {Thorkild I A} and Johannes Hebebrand and Anke Hinney and Thomas Reinehr and S{\o}rensen, {Thorkild I.A.}",
year = "2012",
doi = "10.1038/oby.2011.339",
language = "English",
volume = "20",
pages = "466--70",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents

AU - Scherag, André

AU - Kleber, Michaela

AU - Boes, Tanja

AU - Kolbe, Andreea-Liliana

AU - Ruth, Anne

AU - Grallert, Harald

AU - Illig, Thomas

AU - Heid, Iris M

AU - Toschke, André M

AU - Grau, Katrine

AU - Sørensen, Thorkild I A

AU - Hebebrand, Johannes

AU - Hinney, Anke

AU - Reinehr, Thomas

AU - NUGENOB Consortium

PY - 2012

Y1 - 2012

N2 - Genome-wide association analyses (GWAS) contributed to the detection of a number of single-nucleotide polymorphisms (SNPs) associated with obesity. However, little is known about the impact of the obesity-risk alleles on weight loss-related phenotypes after lifestyle interventions. A recent meta-analysis of GWAS reported five genomic loci near or in the genes FTO, MC4R, TMEM18, SDCCAG8, TNKS/MSRA that were associated with obesity in children and adolescents. Here, we analyzed the effect of the 10 SNPs representative of the five loci on measures of weight loss and cardiometabolic risk after a 1-year lifestyle intervention in 401 children and adolescents (mean age 10.74 years; 55.4% female; mean BMI 27.42 kg/m(2), mean BMI-standard deviation score (SDS) 2.37). For confirmation of one locus genotyping of three intronic SNPs in SDCCAG8 was performed in 626 obese adults who completed the 10-week hypoenergetic diet program. Intronic variants of SDCCAG8, which are associated with early onset obesity, are associated with reduced weight loss after a 1-year lifestyle intervention in overweight children and adolescents even after adjusting for age, sex, baseline measurement, or multiple testing (all P <10(-6)). However, our results could not be confirmed in 626 obese adults undertaking a hypoenergetic diet intervention.

AB - Genome-wide association analyses (GWAS) contributed to the detection of a number of single-nucleotide polymorphisms (SNPs) associated with obesity. However, little is known about the impact of the obesity-risk alleles on weight loss-related phenotypes after lifestyle interventions. A recent meta-analysis of GWAS reported five genomic loci near or in the genes FTO, MC4R, TMEM18, SDCCAG8, TNKS/MSRA that were associated with obesity in children and adolescents. Here, we analyzed the effect of the 10 SNPs representative of the five loci on measures of weight loss and cardiometabolic risk after a 1-year lifestyle intervention in 401 children and adolescents (mean age 10.74 years; 55.4% female; mean BMI 27.42 kg/m(2), mean BMI-standard deviation score (SDS) 2.37). For confirmation of one locus genotyping of three intronic SNPs in SDCCAG8 was performed in 626 obese adults who completed the 10-week hypoenergetic diet program. Intronic variants of SDCCAG8, which are associated with early onset obesity, are associated with reduced weight loss after a 1-year lifestyle intervention in overweight children and adolescents even after adjusting for age, sex, baseline measurement, or multiple testing (all P <10(-6)). However, our results could not be confirmed in 626 obese adults undertaking a hypoenergetic diet intervention.

U2 - 10.1038/oby.2011.339

DO - 10.1038/oby.2011.339

M3 - Journal article

C2 - 22095114

VL - 20

SP - 466

EP - 470

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 2

ER -

ID: 48585388