TY - JOUR

T1 - Gut Microbiota in Psychiatric Disorders

T2 - A Systematic Review

AU - Chen, Long Long

AU - Abbaspour, Afrouz

AU - Mkoma, George F.

AU - Bulik, Cynthia M.

AU - Ruck, Christian

AU - Djurfeldt, Diana

PY - 2021

Y1 - 2021

N2 - Objective: This systematic review sought to comprehensively summarize gut microbiota research in psychiatric disorders following PRISMA guidelines.Methods: Literature searches were performed on databases using keywords involving gutmicrobiota and psychiatric disorders. Articles in English with human participants up until February 13, 2020, were reviewed. Risk of bias was assessed using a modified Newcastle-Ottawa Scale for microbiota studies.Results: Sixty-nine of 4231 identified studies met the inclusion criteria for extraction. In most studies, gut microbiota composition differed between individuals with psychiatric disorders and healthy controls; however, limited consistency was observed in the taxonomic profiles. At the genus level, themost replicated findingswere higher abundance of Bifidobacterium and lower abundance of Roseburia and Faecalibacterium among patients with psychiatric disorders.Conclusions: Gut bacteria that produce short-chain fatty acids, such as Roseburia and Faecalibacterium, could be less abundant in patients with psychiatric disorders, whereas commensal genera, for example, Bifidobacterium, might be more abundant compared with healthy controls. However, most included studies were hampered by methodological shortcomings including small sample size, unclear diagnostics, failure to address confounding factors, and inadequate bioinformatic processing, which might contribute to inconsistent results. Based on our findings, we provide recommendations to improve quality and comparability of future microbiota studies in psychiatry.

AB - Objective: This systematic review sought to comprehensively summarize gut microbiota research in psychiatric disorders following PRISMA guidelines.Methods: Literature searches were performed on databases using keywords involving gutmicrobiota and psychiatric disorders. Articles in English with human participants up until February 13, 2020, were reviewed. Risk of bias was assessed using a modified Newcastle-Ottawa Scale for microbiota studies.Results: Sixty-nine of 4231 identified studies met the inclusion criteria for extraction. In most studies, gut microbiota composition differed between individuals with psychiatric disorders and healthy controls; however, limited consistency was observed in the taxonomic profiles. At the genus level, themost replicated findingswere higher abundance of Bifidobacterium and lower abundance of Roseburia and Faecalibacterium among patients with psychiatric disorders.Conclusions: Gut bacteria that produce short-chain fatty acids, such as Roseburia and Faecalibacterium, could be less abundant in patients with psychiatric disorders, whereas commensal genera, for example, Bifidobacterium, might be more abundant compared with healthy controls. However, most included studies were hampered by methodological shortcomings including small sample size, unclear diagnostics, failure to address confounding factors, and inadequate bioinformatic processing, which might contribute to inconsistent results. Based on our findings, we provide recommendations to improve quality and comparability of future microbiota studies in psychiatry.

KW - autism spectrum disorder

KW - major depressive disorder

KW - anorexia nervosa

KW - bipolar disorder

KW - schizophrenia

KW - attention-deficit/hyperactivity

KW - disorder

KW - gut microbiota

KW - FECAL MICROBIOTA

KW - SODIUM-BUTYRATE

KW - FAECALIBACTERIUM-PRAUSNITZII

KW - ANOREXIA-NERVOSA

KW - AUTISM

KW - ASSOCIATION

KW - DEPRESSION

KW - DIVERSITY

KW - CHILDREN

KW - ANXIETY

U2 - 10.1097/PSY.0000000000000959

DO - 10.1097/PSY.0000000000000959

M3 - Journal article

C2 - 34117156

VL - 83

SP - 679

EP - 692

JO - Psychosomatic Medicine

JF - Psychosomatic Medicine

SN - 0033-3174

IS - 7

ER -